Perindopril Arginine and Amlodipine Tablets 10mg/5mg

Description

What is SEFAM PL 10/5?
SEFAM PL 10/5 contains Perindopril Arginine(an ACE inhibitor) and Amlodipine(a calcium channel blocker).
It is a substitution therapy for the treatment of high blood pressure and/or stable coronary heart disease in patients already controlled with separate doses of perindopril and amlodipine.
Treatment should not be initiated with this combination.
Detailed information related to SEFAM PL 10/5 Tablets’s uses, side-effects, reviews, questions, interactions, and precautions is as follows:

SEFAM PL 10/5 Uses
SEFAM PL 10/5 Tablets is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:

• Hypertension
• Stable Coronary Artery Disease (CAD)
• Congestive Heart Failure (CHF)
• Heart Attack
• Strokes
• Kidney Problems

SEFAM PL 10/5 Working, Mechanism of Action and Pharmacology
SEFAM PL 10/5 improves the patient’s condition by performing the following functions:
Perindopril Arginine-angiotensin converting enzyme(ACE) inhibitor:

• Perindopril Arginine competitively inhibits the conversion of angiotensin I to angiotensin II (a potent endogenous vasoconstrictor) and the bradykinin metabolism; these actions cause dilation of the blood vessels.
• It also inhibits the secretion of aldosterone induced by angiotensin II, which promotes the excretion of sodium and water.

Amlodipine-calcium channel blocker (CCB):

• Amlodipine prevents calcium from entering certain tissues and arteries, causing them to relax.
• As a result, blood can flow more easily to your heart, which in turn helps lower blood pressure.

SEFAM PL 10/5 Composition and active ingredients:
Each film coated SEFAM PL 10/5 Tablets is having various prescription medications as given below:

• Perindopril Arginine 10mg
• Amlodipine Besylate USP
• Equivalent to Amlodipine 5mg
• Colour: Red Iron Oxide, Yellow Iron Oxide, and Titanium Dioxide

SEFAM PL 10/5 – Side-effects
The following is a list of possible side-effects that may occur in medicines that contain SEFAM PL 10/5. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.

• Cough
• Dizziness and Headache
• Back and chest pain
• Abnormal ECG
• Edema
• Tinnitus
• Rash, Itching, Eczema
• Erectile dysfunction

SEFAM PL 10/5 – Precautions & How to Use
Use as directed by your doctor or follow the instructions printed on the product insert.
Consult a doctor, if the condition persists or worsens.
Important counseling points are listed below:

• To prevent dehydration, have plenty of fluids unless the doctor directs you otherwise.
• This product may affect potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult a doctor or pharmacist.
• Do not drive, use heavy machinery, or do anything that needs alertness until it can be done safely.
• Do not use during Lactation and Pregnancy. Consult a doctor first.

Note:
Keep out of reach of the children.