Product Category

Nicorandil

  • Product Name : Nicorandil
  • Grade : IP / BP / USP
  • Therapeutic Category : Antianginals
  • CAS No : 65141-46-0
  • COA : Available
  • MSDS : Available
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Description

Description

Nicorandil is a vasodilatory drug used to treat angina.

Nicorandil stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP).cGMP activates protein kinase G (PKG) which phosphorylates and inhibits GTPase RhoA and decreases Rho-kinase activity. Reduced Rho-kinase activity permits an increase in myosin phosphatase activity, decreasing the calcium sensitivity of the smooth muscle.

 

Specification:

Analysis Test                               Specification       Result
 

Description

 

white crystalline powder,odorless

 

Conforms

 

Solubility

 

Easily soluble in water, unsoluble in ethanol

 

Conforms

PH 6.0~7.5 6.9
 

Solution clarity and color

 

solution should be clear and colorless

 

Conforms

 

Related substances

5’CMP 0.3%

Simple impurity

Total other impurity

0.01%

0.03%

0.10%

 

Chloride

0.05%  

Conforms

 

Ammonium

0.05%  

Conforms

 

Fe

0.01%  

Conforms

 

Phosphate

0.1%  

Conforms

 

Loss on drying

≤6.0% 1.3%
 

Heavy metals

0.002%  

Conforms

 

Arsenide

0.0001%  

Conforms

 

Bacterial Endotoxins

0.3EU/mg  

Conforms

 

Microbial Limit

Conforms  

Conforms

Assay(on dried basis) ≥98.0% 98.8%
Conclusion: The results conform with BP 2010

 

Packaging details:

 

 

Packaging details: 25kg/drum with double plastic bags inside; packed in a cardboard drum or fiber HDPE drum.
Storage: Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat
Shelf Life: 5 years if sealed and store away from direct sun light.

Additional Information

The most widely recognized markets for this item incorporate the accompanying nations. If you don’t mind ask with us if your nation or district isn’t recorded:

ASIA: Afghanistan, Israel, Jordan, Pakistan, Russia, Saudi Arabia, Singapore, Syria, Philippines, Turkey, Turkmenistan, Uzbekistan, Yemen, Vietnam, Indonesia, Malaysia, Iran, Tajikistan, and so forth.

AFRICA: South Africa, Uganda, Nigeria, Ghana, Kenya, Mauritius, Botswana, Egypt, Ethiopia, Libya, Sudan, Congo, Gambia, Ivory Coast , and so forth.

NORTH & SOUTH AMERICA: USA, Canada, Panama, Trinidad and Tobago, Costa Rica, Puerto Rico, Dominican Republic, Argentina, Guatemala, Guyana, Peru, Bolivia, Venezuela , Brazil, Bahamas, Ecuador, and so forth .

EUROPE: Austria , Azerbaijan, Belarus, Belgium, Cyprus, Czech Republic, Denmark, France, Georgia, Germany, Hungary, Ireland, Iceland, Netherlands, Norway, Poland, Spain, Sweden, Switzerland, Ukraine, United Kingdom (UK) , Latvia, and so forth.

OCEANIA: Australia, New Zealand, Fiji, and so forth.