Product Category

Memantin HCl

  • Product Name : Memantin HCl
  • Grade : IP / BP / USP
  • Therapeutic Category : Central Nervous System Agent
  • CAS No : 41100-52-1
  • COA : Available
  • MSDS : Available
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Description

Description

1.Memantine Hydrochloride/Memantine HCL
2. Cas No:41100-52-1
3. MF:C12H21N.HCl
4.Use:Alzheimer’s disease treatment
5. Appearance:White powder

A dysfunction of glutamatergic neurotransmission, manifested as neuronal excitotoxicity, is hypothesized to be involved in the etiology of Alzheimer’s disease. Targeting the glutamatergic system, specifically NMDA receptors, offers a novel approach to treatment in view of the limited efficacy of existing drugs targeting the cholinergic system.

Memantine is a low-affinity voltage-dependent uncompetitive antagonist at glutamatergic NMDA receptors. By binding to the NMDA receptor with a higher affinity than Mg2+ ions, memantine is able to inhibit the prolonged influx of Ca2+ ions which forms the basis of neuronal excitotoxicity. The low affinity and rapid off-rate kinetics of memantine at the level of the NMDA receptor-channel, however, preserves the physiological function of the receptor as it can still be activated by the relatively high concentrations of glutamate released following depolarization of the presynaptic neuron.

Packaging details:

Packaging details: 25kg/drum with double plastic bags inside; packed in a cardboard drum or fiber HDPE drum.
Storage: Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat
Shelf Life: 5 years if sealed and store away from direct sun light.

Additional Information

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EUROPE: Austria , Azerbaijan, Belarus, Belgium, Cyprus, Czech Republic, Denmark, France, Georgia, Germany, Hungary, Ireland, Iceland, Netherlands, Norway, Poland, Spain, Sweden, Switzerland, Ukraine, United Kingdom (UK) , Latvia, and so forth.

OCEANIA: Australia, New Zealand, Fiji, and so forth.